PB2307 SICKLE CELL DISEASE PATIENTS HAVE NORMAL NEUTROPHIL OXIDATIVE BURST RESPONSE
نویسندگان
چکیده
منابع مشابه
Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1.
Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during granulopoiesis, impairing the ability of developing neutrophils to mount a bactericidal oxidative burst, and increasing susceptibility to bacterial i...
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In the 18th century, Priestley, Scheele and Lavoisier discovered oxygen and reported its critical role and toxic effects in living organisms. In the last century, several studies highlighted the importance of biological oxidation for energy production by aerobic organisms, in defense and the elimination of drugs. Oxidation is mediated by oxidants and free radicals, generically called reactive o...
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Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, polymorphonuclear neutrophils can form neutrophil extracellular traps. Neutrophil extracellular traps consist of a meshwork of extracellular DNA, nucleosomes, histones and neutrophil proteases. Neutrophil extracellular traps have been demonstrated to ...
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Abstract Background Prevalence of hereditary blood diseases such as sickle cell anemia, sickle thalassemia and thalassemia major are high in Khuzestan province. Sickle cell anemia and beta-thalassemia are predominantly common in Iranian Arabs. Pulmonary complications account for a large proportion of morbidity and mortality in patients with and sickle cell disease. Periodic lung function asse...
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ژورنال
عنوان ژورنال: HemaSphere
سال: 2019
ISSN: 2572-9241
DOI: 10.1097/01.hs9.0000567696.56159.30